Description

4-Chlorotoluene-2-Sulphonyl Chloride is a key aromatic sulfonyl chloride derivative, serving as a versatile and reactive chemical intermediate in advanced organic synthesis. Its primary value lies in its ability to act as a sulfonating agent, enabling the introduction of the sulfonyl functional group to construct more complex molecules. This compound is essential for research chemists and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity building blocks for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of sulfonamide-based drugs, including diuretics, antibacterial agents, and protease inhibitors.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators that incorporate sulfonylurea or sulfonamide moieties.
• Dyestuff and Pigment Manufacturing: Acts as a precursor in the creation of sulfonated dyes and organic pigments, enhancing color fastness and solubility.
• Polymer Modification: Employed to introduce sulfonyl chloride groups into polymer chains for subsequent functionalization, improving material properties.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D for exploring new synthetic pathways and creating novel chemical entities.
• Cross-coupling Reactions: Serves as an electrophile in palladium-catalyzed cross-coupling reactions to form carbon-sulfur bonds.

Basic Information

Product Name	4-Chlorotoluene-2-Sulphonyl Chloride
CAS No.	34981-38-9
Molecular Formula	C7H6Cl2O2S
Molecular Weight	225.09 g/mol
Synonyms	2-Chloro-4-methylbenzenesulfonyl chloride; 4-Methyl-2-chlorobenzenesulfonyl chloride; p-Toluenesulfonyl chloride, 2-chloro-; 2-Chloro-p-toluenesulfonyl chloride; 4-Chloro-2-methylbenzenesulfonyl chloride; 2-Chloro-4-toluenesulfonyl chloride; 4-Chloro-o-toluenesulfonyl chloride; Benzenesulfonyl chloride, 2-chloro-4-methyl-
EINECS	Contact for details

Quality Control

Our 4-Chlorotoluene-2-Sulphonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or lumps
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	64 - 68 °C
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.