Description

1-(5-Bromofuran-2-Yl)-2,2,2-Trifluoroethan-1-One is a high-value, multi-functional organofluorine building block essential for advanced chemical synthesis. Its unique structure, featuring both a reactive bromofuran moiety and a trifluoroacetyl group, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and materials science industries for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring furan and fluorine motifs to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and insecticides, where the bromine and fluorine atoms contribute to enhanced biological activity and environmental profile.
• Material Science Research: Acts as a building block for creating specialized polymers, liquid crystals, and organic electronic materials due to its ability to introduce both halogen and fluorinated functional groups.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille), enabling the construction of complex biaryl and heteroaryl systems.
• Fluorine Chemistry: A valuable reagent for introducing the trifluoroacetyl group into target molecules, a common strategy in medicinal chemistry to improve lipophilicity and binding affinity.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating novel chemical entities for screening libraries.

Basic Information

Product Name	1-(5-Bromofuran-2-Yl)-2,2,2-Trifluoroethan-1-One
CAS No.	34773-56-3
Molecular Formula	C6H2BrF3O2
Molecular Weight	242.98 g/mol
Synonyms	5-Bromo-2-furyl trifluoromethyl ketone; 2-Acetyl-5-bromofuran, trifluoro derivative; 5-Bromo-2-(trifluoroacetyl)furan; 1-(5-Bromo-2-furanyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(5-bromofuran-2-yl)ethanone; 5-Bromo-α,α,α-trifluoro-2-furanmethanone; 5-Bromo-2-trifluoroacetylfuran
EINECS	Contact for details

Quality Control

Our 1-(5-Bromofuran-2-Yl)-2,2,2-Trifluoroethan-1-One is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We adhere to cGMP principles where applicable to support our clients in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.