Description

1-(5-Bromothiophen-2-Yl)-2,2,2-Trifluoroethanone is a high-purity, specialized organic building block featuring a reactive trifluoroacetyl group adjacent to a brominated thiophene ring. This compound matters for its role as a critical intermediate in the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the life sciences sector for constructing novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing thiophene and fluorine motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used in developing novel herbicides, fungicides, and insecticides where the bromine atom allows for further functionalization.
• Material Science: Serves as a precursor for organic electronic materials, such as conductive polymers and organic semiconductors, leveraging the thiophene backbone.
• Ligand and Catalyst Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry: A valuable reagent for introducing the trifluoroacetyl group into target molecules, a common moiety in medicinal chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthetic routes.

Basic Information

Product Name	1-(5-Bromothiophen-2-Yl)-2,2,2-Trifluoroethanone
CAS No.	34773-51-8
Molecular Formula	C6H2BrF3OS
Molecular Weight	258.04 g/mol
Synonyms	5-Bromo-2-thenoyltrifluoroacetone; 5-Bromo-2-thenoyltrifluoroacetone; 2,2,2-Trifluoro-1-(5-bromothiophen-2-yl)ethanone; 1-(5-Bromo-2-thienyl)-2,2,2-trifluoroethanone; 5-Bromo-2-(trifluoroacetyl)thiophene; 5-Bromothiophene-2-carboxylic acid trifluoromethyl ketone; BTTA; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 1-(5-Bromothiophen-2-Yl)-2,2,2-Trifluoroethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We can support development projects requiring compliance with cGMP or other regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.