Description

Lathyrol is a diterpenoid natural product derived from the seeds of *Euphorbia lathyris* (Caper Spurge). This compound serves as a key intermediate in the synthesis of ingenol mebutate, a pharmaceutical agent approved for the topical treatment of actinic keratosis. It is primarily sought by manufacturers in the pharmaceutical and fine chemical sectors for research, development, and production of high-value active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Critical precursor in the semi-synthesis of ingenol mebutate (Picato®).
• Medicinal Chemistry Research: Used as a scaffold for developing novel diterpenoid-based therapeutic agents.
• Biochemical Research: Studied for its biological activities and structure-activity relationships (SAR).
• Fine Chemical Synthesis: Serves as a building block for complex organic molecules in specialty chemistry.
• Reference Standard: Utilized as an analytical standard in quality control laboratories for HPLC and LC-MS methods.

Basic Information

Product Name	Lathyrol
CAS No.	34420-19-4
Molecular Formula	C20H28O5
Molecular Weight	348.44 g/mol
Synonyms	(-)-Lathyrol; Lathyrol, (-)-; Ingenol precursor; (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-5,5a,6,9,10,10a-Hexahydro-1a,2,5,8a-tetrahydroxy-5,9-dimethyl-3H-naphtho[2,1-c]pyran-3,7(1aH)-dione; Euphorbia factor L1; CAS 34420-19-4
EINECS	Contact for details

Quality Control

Our Lathyrol is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with cGMP, ICH Q7 guidelines, and relevant pharmacopeial standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.