Description

2-O,3-O,4-O,5-O,6-o-Pentakis(Trimethylsilyl)-D-Gluconic Acid Trimethylsilyl Ester is a fully silylated derivative of D-gluconic acid, designed to provide enhanced stability and solubility for advanced synthetic applications. This high-purity reagent is critical for protecting hydroxyl groups and facilitating complex organic transformations where moisture sensitivity is a primary concern. It is an essential building block for researchers and manufacturers in pharmaceutical development, specialty chemical synthesis, and analytical chemistry.

Application

• Pharmaceutical Intermediate: Serves as a key protected synthon in the multi-step synthesis of complex drug molecules, particularly in carbohydrate-based therapeutics.
• Derivatization Agent for GC/MS Analysis: Used to convert polar, non-volatile compounds (like sugars and polyols) into volatile trimethylsilyl (TMS) ethers for accurate gas chromatography-mass spectrometry analysis.
• Advanced Organic Synthesis: Acts as a versatile precursor or protecting group reagent in stereoselective synthesis and the preparation of chiral ligands or catalysts.
• Polymer & Material Science: Employed in the synthesis of functionalized polymers or surface-modifying agents where the introduction of a protected sugar acid moiety is required.
• Biochemical Research: Utilized in metabolic studies and the synthesis of labeled compounds for tracer experiments.

Basic Information

Product Name	2-O,3-O,4-O,5-O,6-o-Pentakis(Trimethylsilyl)-D-Gluconic Acid Trimethylsilyl Ester
CAS No.	34290-52-3
Molecular Formula	C24H58O7Si6
Molecular Weight	635.28 g/mol
Synonyms	D-Gluconic acid, pentakis(trimethylsilyl) ester, trimethylsilyl ester; Pentakis-O-(trimethylsilyl)-D-gluconic acid trimethylsilyl ester; Gluconic acid pentatrimethylsilyl ether TMS ester; Fully silylated D-gluconic acid TMS ester; Hexa(trimethylsilyl) D-gluconate; TMS-D-gluconate per-TMS; 34290-52-3
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our silylation reagents. Each batch of 2-O,3-O,4-O,5-O,6-o-Pentakis(Trimethylsilyl)-D-Gluconic Acid Trimethylsilyl Ester is analyzed to ensure high chemical purity and consistency, meeting the exacting standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by GC or HPLC), and moisture content is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.