Description

L-Phe(3-Oh)-Ome.Hcl CAS NO 34260-72-5 is a chemically modified derivative of the amino acid L-phenylalanine, specifically hydroxylated at the 3-position and esterified as the methyl ester hydrochloride salt. This compound is a crucial chiral building block and intermediate in advanced organic synthesis, particularly for the development of novel pharmaceuticals and bioactive peptides. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, peptide synthesis, and the development of enzyme inhibitors or receptor ligands.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and metabolic disorder therapeutics.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to incorporate modified phenylalanine residues, altering peptide stability, bioavailability, and receptor binding affinity.
• Medicinal Chemistry Research: Serves as a precursor for creating focused libraries of compounds in drug discovery programs targeting specific enzymes or biological pathways.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to investigate tyrosine hydroxylase or phenylalanine metabolism-related processes.
• Asymmetric Synthesis: Utilized as a starting material or auxiliary in stereoselective synthesis due to its defined chiral center, facilitating the construction of complex molecules.

Basic Information

Product Name	L-Phe(3-Oh)-Ome.Hcl
CAS No.	34260-72-5
Molecular Formula	C10H14ClNO3
Molecular Weight	231.68 g/mol
Synonyms	L-3-Hydroxyphenylalanine methyl ester hydrochloride; (S)-2-Amino-3-(3-hydroxyphenyl)propionic acid methyl ester hydrochloride; Methyl L-β-(3-hydroxyphenyl)alaninate hydrochloride; L-Tyrosine O-methyl ether hydrochloride (common misnomer); H-L-3-Hyp-OMe·HCl; 3-HO-L-Phe-OMe·HCl
EINECS	Contact for details

Quality Control

Our L-Phe(3-Oh)-Ome.Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, chiral analysis to confirm enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. Certificates of Analysis (COA) with detailed chromatographic data are provided to ensure compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the certificate of analysis. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment and allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.