Description

(2R,3R,4S,5S)-4-(Aminomethyl)Cubane-1-Carboxylic Acid Hydrochloride is a high-purity, stereochemically defined derivative of the rigid cubane scaffold. This compound is valued for its unique three-dimensional structure and functional handles, making it a critical building block in advanced pharmaceutical and materials research. It is primarily sought by R&D chemists and process development scientists working on novel drug candidates, high-energy materials, and specialty polymers where precise spatial orientation is paramount.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders and other therapeutic areas.
• Advanced Materials Research: Used as a precursor for high-density, high-stability polymers and energetic materials, leveraging the cubane cage's strain energy and thermal stability.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and bioconjugates where a rigid, non-natural spacer is required to study protein-ligand interactions.
• Asymmetric Synthesis: Acts as a chiral auxiliary or a template in stereoselective synthesis to induce specific three-dimensional configurations in target molecules.
• Academic & Industrial R&D: A valuable reagent for exploratory chemistry in universities and corporate research labs focusing on novel carbon frameworks and their properties.

Basic Information

Product Name	(2R,3R,4S,5S)-4-(Aminomethyl)Cubane-1-Carboxylic Acid Hydrochloride
CAS No.	34132-07-5
Molecular Formula	C11H15NO2 • HCl
Molecular Weight	229.70 g/mol (Free base: 193.24 g/mol)
Synonyms	4-(Aminomethyl)cubane-1-carboxylic acid hydrochloride; (1R,2R,3S,4S)-4-(Aminomethyl)pentacyclo[4.2.0.02,5.03,8.04,7]octane-1-carboxylic acid hydrochloride; Cubane-1,4-dicarboxylic acid monoamide hydrochloride derivative; Chiral Cubane Amino Acid Hydrochloride; 1-Carboxy-4-aminomethylcubane HCl; Aminomethylcubanecarboxylic Acid HCl
EINECS	Contact for details

Quality Control

Our (2R,3R,4S,5S)-4-(Aminomethyl)Cubane-1-Carboxylic Acid Hydrochloride is manufactured under strict quality control protocols to ensure high chemical and chiral purity, essential for sensitive research and development applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles. We adhere to cGMP principles for advanced intermediates, ensuring traceability and batch-to-batch consistency for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.