Description

2-Ethynyloxetane is a highly reactive, strained heterocyclic building block containing both an oxetane ring and a terminal alkyne functional group. This unique bifunctional structure makes it a critical intermediate for advanced material science and pharmaceutical research, enabling the synthesis of complex molecular architectures. It is primarily sought by R&D chemists and process development scientists in the fields of medicinal chemistry, polymer science, and agrochemical discovery for constructing novel compounds with tailored properties.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the development of new active pharmaceutical ingredients (APIs), particularly for introducing the oxetane moiety to modulate solubility, metabolic stability, and potency.
• Click Chemistry Reagent: The terminal alkyne group enables efficient, copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation, polymer functionalization, and material surface modification.
• Polymer & Material Science: Used as a monomer or cross-linker for synthesizing advanced polymers with unique thermal, mechanical, or optical properties, including high-performance resins and coatings.
• Agrochemical Research: Employed in the discovery and synthesis of novel herbicides, fungicides, and plant growth regulators.
• Ligand & Catalyst Development: Acts as a precursor for creating specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Dendrimer & Macromolecule Construction: Facilitates the controlled, step-wise assembly of complex dendritic structures due to its orthogonal reactivity.

Basic Information

Product Name	2-Ethynyloxetane
CAS No.	33869-43-1
Molecular Formula	C5H6O
Molecular Weight	82.10 g/mol
Synonyms	2-Ethynyloxetane; Oxetane, 2-ethynyl-; 2-Ethynyl-1,3-propylene oxide; 3-Oxetanemethanol, 2-ethynyl-; 2-Ethynyloxacyclobutane; Propargyl oxetane; Terminal alkyne oxetane; 33869-43-1
EINECS	Contact for details

Quality Control

Every batch of 2-Ethynyloxetane is produced and analyzed under strict quality management protocols to ensure consistency and purity for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity (by GC or HPLC), identity confirmation (by FT-IR and/or NMR), and impurity profiles. Our quality system is designed to support cGMP and ISO standards for traceability and reliability.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties of being easily oxidized (store under inert atmosphere) and highly volatile, this material should be stored under an inert gas (argon or nitrogen) in a cool, well-ventilated place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to reach room temperature before opening to minimize moisture ingress and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to reference spectrum
Purity (GC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.