Description

Glycine, n-Acetyl-n-(Trifluoroacetyl)-, Methyl Ester is a specialized fluorinated amino acid derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both acetyl and trifluoroacetyl protecting groups, makes it a valuable reagent for introducing fluorine motifs into peptides and other bioactive molecules. This compound is essential for researchers and manufacturers in pharmaceutical development, agrochemical research, and materials science, where precise molecular modification is required.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel fluorinated peptide-based drugs and protease inhibitors.
• Agrochemical Synthesis: Used in creating advanced fluorinated active ingredients for crop protection products with enhanced efficacy and environmental profiles.
• Peptide Chemistry: Serves as a protected glycine derivative for solid-phase and solution-phase peptide synthesis, enabling complex sequence assembly.
• Bioconjugation & Probe Development: Utilized in the synthesis of fluorescent or isotopic labels and cross-linking agents for biochemical and diagnostic applications.
• Material Science Research: Acts as a precursor for fluorinated polymers and specialty materials with unique surface properties.
• Chemical Biology Tool: Employed in studying enzyme mechanisms and protein interactions where fluorine acts as a spectroscopic or steric probe.

Basic Information

Product Name	Glycine, n-Acetyl-n-(Trifluoroacetyl)-, Methyl Ester
CAS No.	33845-37-3
Molecular Formula	C7H8F3NO4
Molecular Weight	227.14 g/mol
Synonyms	N-Acetyl-N-(trifluoroacetyl)glycine methyl ester; Methyl N-acetyl-N-(trifluoroacetyl)glycinate; Ac-Gly(Tfa)-OMe; N-Acetyl-N-trifluoroacetylglycine methyl ester; Glycine, N-acetyl-N-(trifluoroacetyl)-, methyl ester; Methyl 2-(acetylamino)-2-(trifluoroacetyl)acetate; 2-(Acetylamino)-2-(trifluoroacetyl)acetic acid methyl ester
EINECS	Contact for details

Quality Control

Every batch of Glycine, n-Acetyl-n-(Trifluoroacetyl)-, Methyl Ester is produced and tested under a strict quality management system to ensure consistency and reliability for your critical applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our standard analytical methods include HPLC, NMR, and IR spectroscopy to meet the exacting requirements of research and development laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.