Description

3-O,4-O,5-o-Tris(Trimethylsilyl)-D-Fructose 1,6-Bis[Phosphoric Acid Bis(Trimethylsilyl)] Ester is a highly derivatized, silyl-protected analog of D-fructose 1,6-bisphosphate, a key intermediate in glycolysis. This compound is specifically engineered to provide enhanced stability and solubility in organic solvents, making it a critical reagent for advanced synthetic and analytical chemistry. It is primarily sought by researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries for applications requiring protected sugar phosphates.

Application

• Chemical Synthesis Intermediate: Serves as a protected building block for the synthesis of complex carbohydrates, nucleosides, and other bioactive molecules.
• Pharmaceutical Research: Used in the development and study of metabolic pathway inhibitors, enzyme substrates, and prodrugs.
• Analytical Chemistry Standard: Acts as a reference standard or derivatization agent in chromatographic (GC, LC) and mass spectrometric analysis of sugar phosphates.
• Biochemistry Studies: Employed in mechanistic studies of glycolytic enzymes where a stable, non-hydrolyzable substrate analog is required.
• Agrochemical Development: Potential intermediate in the synthesis of novel sugar-based active ingredients or adjuvants.
• Material Science: Exploration of silylated sugar derivatives for creating specialized polymers or surface coatings.

Basic Information

Product Name	3-O,4-O,5-o-Tris(Trimethylsilyl)-D-Fructose 1,6-Bis[Phosphoric Acid Bis(Trimethylsilyl)] Ester
CAS No.	33800-33-8
Molecular Formula	C27H69O11P2Si7
Molecular Weight	879.5 g/mol (approx.)
Synonyms	D-Fructose 1,6-bisphosphate tris(trimethylsilyl) ether bis(trimethylsilyl) ester; Per-TMS-D-Fructose-1,6-diphosphate; 1,6-Bis-O-(bis(trimethylsilyl)phosphoryl)-2,3,4,5-tetra-O-trimethylsilyl-D-fructose; Hexakis(trimethylsilyl) D-fructose 1,6-bisphosphate; TMS-Fructose-1,6-bisP; Fully silylated fructose-1,6-diphosphate; Fructose-1,6-bisphosphate per(trimethylsilyl) derivative
EINECS	Contact for details

Quality Control

Our 3-O,4-O,5-o-Tris(Trimethylsilyl)-D-Fructose 1,6-Bis[Phosphoric Acid Bis(Trimethylsilyl)] Ester is produced under controlled conditions to ensure high purity and batch-to-batch consistency. Each lot undergoes rigorous analytical testing, including NMR (¹H, ¹³C, ³¹P), HPLC, and GC analysis, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to strict quality management protocols suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when opening the container to prevent hydrolysis and degradation. For long-term storage, consider storing under inert gas in a desiccator.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.