Description

5,6,7,8-Tetrafluorocoumarin is a specialized fluorinated derivative of the coumarin scaffold, serving as a high-value synthetic intermediate. This compound is prized for its unique electronic properties imparted by the tetrafluoro substitution, which makes it a critical building block in advanced material and pharmaceutical research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries for constructing complex molecules with enhanced stability and activity.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS and oncology.
• Agrochemical Synthesis: Used in developing advanced pesticides and herbicides where the fluorinated coumarin core contributes to improved bioavailability and environmental persistence.
• Organic Light-Emitting Diodes (OLEDs): Acts as an electron-transport material or a core unit for emissive layers in display and lighting technologies.
• Fluorescent Probe & Dye Development: Serves as a starting material for creating sensitive fluorescent tags and sensors used in bioimaging and analytical chemistry.
• Academic & Industrial R&D: A versatile scaffold for medicinal chemistry, material science, and synthetic methodology research in university and corporate laboratories.
• Polymer & Material Science: Incorporated into specialty polymers to modify thermal stability, optical properties, and surface characteristics.

Basic Information

Product Name	5,6,7,8-Tetrafluorocoumarin
CAS No.	33739-04-7
Molecular Formula	C9H2F4O2
Molecular Weight	218.11 g/mol
Synonyms	5,6,7,8-Tetrafluoro-2H-chromen-2-one; 5,6,7,8-Tetrafluoro-2H-1-benzopyran-2-one; Tetrafluorocoumarin; 2H-1-Benzopyran-2-one, 5,6,7,8-tetrafluoro-; Coumarin, 5,6,7,8-tetrafluoro-; 33739-04-7 (CAS); 5,6,7,8-Tetrafluorocumarin
EINECS	Contact for details

Quality Control

Our 5,6,7,8-Tetrafluorocoumarin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and heavy metals. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is light-sensitive (store away from light). Keep container tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.