Description

(4-Methoxyphenyl)Glycolonitrile is a versatile aromatic nitrile building block characterized by its methoxy-substituted phenyl ring. This compound matters as a key chiral intermediate in the synthesis of complex pharmaceutical molecules and fine chemicals, offering a reactive nitrile group for further functionalization. It is primarily needed by research and development laboratories, pharmaceutical manufacturers, and agrochemical producers for constructing active pharmaceutical ingredients (APIs), ligands, and advanced material precursors.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the production of β-blockers, adrenergic agents, and other cardiovascular or neurological active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the manufacture of herbicides and pesticides, leveraging its aromatic structure for bioactive molecule design.
• Fine Chemical Production: Serves as a precursor for dyes, pigments, and specialty polymers where the methoxyphenyl group imparts specific electronic or structural properties.
• Ligand and Catalyst Development: Employed in asymmetric synthesis to create chiral ligands for metal-catalyzed reactions.
• Research & Development: A valuable building block in medicinal chemistry for structure-activity relationship (SAR) studies and novel compound library generation.
• Chemical Synthesis: The nitrile functionality allows for conversion to carboxylic acids, amides, amines, and heterocycles, enabling diverse synthetic pathways.

Basic Information

Product Name	(4-Methoxyphenyl)Glycolonitrile
CAS No.	33646-40-1
Molecular Formula	C9H9NO2
Molecular Weight	163.17 g/mol
Synonyms	4-Methoxymandelonitrile; (4-Methoxyphenyl)(hydroxy)acetonitrile; p-Methoxymandelonitrile; 2-Hydroxy-2-(4-methoxyphenyl)acetonitrile; α-Hydroxy-4-methoxybenzeneacetonitrile; 4-Methoxybenzaldehyde cyanohydrin; 4-Methoxyphenylglycolonitrile; p-Methoxyphenylglycolonitrile
EINECS	Contact for details

Quality Control

Our (4-Methoxyphenyl)Glycolonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing purity, impurity profile, and physical characteristics are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.