Description

D-Proline, 4-Fluoro-5-Oxo-, (4S)-Rel- (9Ci) is a fluorinated, non-natural derivative of the amino acid proline, characterized by its specific stereochemistry and a ketone group at the 5-position. This compound is a high-value chiral building block critical for the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic research labs focused on medicinal chemistry, peptide mimetics, and the development of enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for protease inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used to introduce conformational constraints and fluorine atoms into peptide backbones to enhance metabolic stability, bioavailability, and binding affinity.
• Peptidomimetics Development: Serves as a proline analog for creating novel peptide-like structures with improved pharmacological properties.
• Asymmetric Synthesis Catalyst Ligand: Potential use as a precursor for chiral ligands or organocatalysts in enantioselective synthesis.
• Biochemical Research: Used as a tool compound in enzymatic studies to investigate substrate specificity and inhibition mechanisms.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Item	Details
Product Name	D-Proline, 4-Fluoro-5-Oxo-, (4S)-Rel- (9Ci)
CAS No.	33524-00-4
Molecular Formula	C5H6FNO3
Molecular Weight	147.10 g/mol
Synonyms	(4S)-4-Fluoro-5-oxo-D-proline; (4S)-4-Fluoropyroglutamic acid; (4S)-4-Fluoro-5-oxopyrrolidine-2-carboxylic acid; 4-Fluoro-D-pyroglutamic acid; 4-Fluoro-5-oxo-D-proline; Rel-(4S)-4-Fluoro-5-oxo-D-proline; (2R,4S)-4-Fluoro-5-oxopyrrolidine-2-carboxylic acid; 4-Fluoro-5-oxo-D-proline (9CI)
EINECS	Contact for details

Quality Control

Our D-Proline, 4-Fluoro-5-Oxo-, (4S)-Rel- (9Ci) is produced under strict quality management systems suitable for research and development applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to confirm stereochemical integrity. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.