Description

3,17α-Bis(Trimethylsiloxy)-1,3,5(10)-Estratriene is a high-purity, organosilicon-protected derivative of estradiol, serving as a critical advanced intermediate in complex organic synthesis. Its primary value lies in providing a stable, reactive handle for the selective functionalization of steroid cores, enabling the development of novel pharmaceutical compounds and research materials. This compound is essential for R&D chemists and process developers in the pharmaceutical, biotechnology, and fine chemical industries who require precise molecular building blocks for hormone-related drug discovery and synthesis.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the research and development of steroidal drugs and hormone therapies.
• Organic Synthesis Building Block: Used for the selective introduction of functional groups at protected positions on the estrane skeleton.
• Research & Development: Critical material in academic and industrial labs for studying steroid chemistry and metabolic pathways.
• Process Chemistry: Employed in scaling up synthetic routes for active pharmaceutical ingredients (APIs) with steroidal backbones.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	3,17α-Bis(Trimethylsiloxy)-1,3,5(10)-Estratriene
CAS No.	33283-14-6
Molecular Formula	C24H40O2Si2
Molecular Weight	416.75 g/mol
Synonyms	3,17α-Bis(trimethylsilyloxy)estra-1,3,5(10)-triene; Estra-1,3,5(10)-triene-3,17α-diol, bis(trimethylsilyl) ether; 3,17α-Bis-O-(trimethylsilyl)estradiol; 3,17α-Di-O-TMS-estradiol; Bis(trimethylsiloxy)estratriene; TMS-Estradiol Derivative; 33283-14-6; Estratriene bis(trimethylsilyl ether)
EINECS	Contact for details

Quality Control

Every batch of 3,17α-Bis(Trimethylsiloxy)-1,3,5(10)-Estratriene is manufactured and tested under strict quality management systems to ensure consistency and reliability for your critical applications. Our products undergo rigorous analytical testing, including HPLC, GC, and NMR, to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.