Description

n-Benzyl (S)-β-(Carboxyamino)-Hydrocinnamic Acid Methyl Ester is a high-purity chiral building block and synthetic intermediate of significant importance in advanced organic synthesis. Its value lies in its protected amino acid derivative structure, which is crucial for constructing complex, biologically active molecules with precise stereochemistry. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of peptide mimetics, enzyme inhibitors, and novel therapeutic agents, particularly within medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for protease inhibitors and other peptide-based therapeutics.
• Peptidomimetic Synthesis: Used to introduce constrained, non-natural amino acid residues into peptide chains to enhance stability, bioavailability, and target selectivity.
• Medicinal Chemistry Research: Serves as a versatile building block for constructing focused libraries of compounds in drug discovery programs targeting various diseases.
• Chemical Biology Probes: Employed in the synthesis of labeled or modified peptides used as tools to study enzyme mechanisms and protein-protein interactions.
• Process Chemistry: Utilized in the scale-up and optimization of synthetic routes for complex molecules during late-stage development and manufacturing.

Basic Information

Product Name	n-Benzyl (S)-β-(Carboxyamino)-Hydrocinnamic Acid Methyl Ester
CAS No.	32975-59-0
Molecular Formula	C19H21NO4
Molecular Weight	327.38 g/mol
Synonyms	(S)-3-[[(Benzyloxy)carbonyl]amino]-3-(2-carboxyethyl)benzenepropanoic acid methyl ester; Methyl (S)-3-[[(Benzyloxy)carbonyl]amino]-3-(2-carboxyethyl)benzenepropanoate; (S)-N-Cbz-3-Amino-3-(2-carboxyethyl)benzenepropanoic acid methyl ester; Cbz-(S)-Amino Acid Derivative; Z-(S)-AACH-OH Methyl Ester; (S)-β-(Carbobenzyloxyamino)hydrocinnamic acid methyl ester; Benzyl (S)-N-(3-methoxy-3-oxo-1-phenylpropyl)carbamate (related form)
EINECS	Contact for details

Quality Control

Our n-Benzyl (S)-β-(Carboxyamino)-Hydrocinnamic Acid Methyl Ester is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is characterized and tested using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; therefore, the container should be kept tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.