Description

6-Deoxy-1-O,2-O:3-O,5-o-Bis(Isopropylidene)-α-D-Glucofuranose is a high-value, protected carbohydrate intermediate essential for synthetic organic chemistry. This compound matters because it provides a strategically blocked sugar scaffold, enabling precise and efficient synthesis of complex nucleosides, antiviral agents, and other bioactive molecules without unwanted side reactions. Pharmaceutical researchers, agrochemical developers, and fine chemical manufacturers need this reliable building block to advance their R&D and production of sophisticated active ingredients.

Application

• Nucleoside & Nucleotide Analog Synthesis: A key protected intermediate for constructing the sugar moiety in antiviral and anticancer drug candidates.
• Antiviral Pro-drug Development: Used in the research and production of modified nucleosides targeting viruses like HCV, HIV, and SARS-CoV-2.
• Carbohydrate Chemistry & Glycosylation: Serves as a versatile starting material for the stereoselective synthesis of complex oligosaccharides and glycoconjugates.
• Pharmaceutical Intermediate: A critical building block in multi-step syntheses for Active Pharmaceutical Ingredients (APIs) in various therapeutic areas.
• Agrochemical Synthesis: Employed in creating novel, biologically active compounds for crop protection and agricultural chemistry.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic synthesis and medicinal chemistry research.
• Chiral Pool Synthesis: Utilized as a chiral template for the asymmetric synthesis of non-carbohydrate natural products and fine chemicals.

Basic Information

Product Name	6-Deoxy-1-O,2-O:3-O,5-o-Bis(Isopropylidene)-α-D-Glucofuranose
CAS No.	32785-99-2
Molecular Formula	C₁₂H₂₀O₅
Molecular Weight	244.28 g/mol
Synonyms	1,2:3,5-Di-O-isopropylidene-6-deoxy-α-D-glucofuranose; 6-Deoxy-1,2:3,5-di-O-isopropylidene-α-D-glucofuranose; 1,2:3,5-Di-O-isopropylidene-6-deoxy-D-glucofuranose; Diacetone-6-deoxyglucose; 6-Deoxy-di-O-isopropylidene glucose; α-D-6-Deoxyglucofuranose 1,2:3,5-bis(isopropylidene) acetal; Protected 6-deoxyglucose derivative
EINECS	Contact for details

Quality Control

Every batch of 6-Deoxy-1-O,2-O:3-O,5-o-Bis(Isopropylidene)-α-D-Glucofuranose is produced and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and optical rotation measurement, to ensure high chemical purity and consistent stereochemical integrity. Certificates of Analysis (COA) with full batch traceability are provided to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]²⁰D	-40° to -44° (c=1 in CHCl₃)
Melting Point	98°C - 102°C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.