Description

1-[5-o-[Bis(Trimethylsiloxy)Phosphinyl]-3-o-Trimethylsilyl-2-Deoxy-β-D-Erythro-Pentofuranosyl]-4-Trimethylsilyloxypyrimidin-2(1H)-One is a sophisticated, silyl-protected nucleoside derivative that serves as a critical building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring high-purity intermediates for the development of novel pharmaceuticals and oligonucleotides. It is primarily utilized in the synthesis of complex nucleoside analogs, making it a key material for pharmaceutical R&D and fine chemical production targeting antiviral and anticancer therapies.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Oligonucleotide Synthesis: Used as a protected monomer in the solid-phase synthesis of modified DNA and RNA strands for research and therapeutic applications.
• Prodrug Development: Employed in creating prodrug forms of nucleoside analogs to enhance bioavailability and targeting.
• Chemical Biology Research: Serves as a tool compound for studying enzyme mechanisms and nucleic acid interactions.
• Fine Chemical Synthesis: Acts as a specialized building block for constructing complex molecular architectures in custom synthesis projects.
• Process Chemistry: Used in route development and scale-up for the commercial manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Item	Details
Product Name	1-[5-o-[Bis(Trimethylsiloxy)Phosphinyl]-3-o-Trimethylsilyl-2-Deoxy-β-D-Erythro-Pentofuranosyl]-4-Trimethylsilyloxypyrimidin-2(1H)-One
CAS No.	32645-61-7
Molecular Formula	C22H48N2O8PSi4
Molecular Weight	621.0 g/mol (approx.)
Synonyms	5'-O-[Bis(trimethylsiloxy)phosphinyl]-3'-O-trimethylsilylthymidine; 3',5'-Di-O-(trimethylsilyl)thymidine cyclic phosphite; Thymidine 3',5'-cyclic phosphite, 3',5'-bis(trimethylsilyl) ether; 2'-Deoxythymidine 3',5'-bis(trimethylsilyl) cyclic phosphite; 1-[5-O-[Bis(trimethylsiloxy)phosphinyl]-3-O-trimethylsilyl-2-deoxy-β-D-erythro-pentofuranosyl]-4-(trimethylsiloxy)-2(1H)-pyrimidinone; TBDMS-Thymidine Cyclic Phosphite
EINECS	Contact for details

Quality Control

Our 1-[5-o-[Bis(Trimethylsiloxy)Phosphinyl]-3-o-Trimethylsilyl-2-Deoxy-β-D-Erythro-Pentofuranosyl]-4-Trimethylsilyloxypyrimidin-2(1H)-One is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical research and development. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.