Description

Diethyl 3-Hydroxyglutarate is a versatile diester of 3-hydroxyglutaric acid, serving as a key chiral building block and intermediate in organic synthesis. Its value lies in its bifunctional structure, featuring both ester and hydroxyl groups, which enables its use in constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs), natural products, and advanced materials.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the production of statin drugs, β-lactam antibiotics, and other bioactive molecules.
• Agrochemical Synthesis: Used in the manufacture of advanced pesticides and herbicides requiring specific stereochemistry.
• Polymer & Resin Modifier: Acts as a monomer or cross-linking agent to introduce hydroxyl functionality into polymers, improving adhesion and flexibility.
• Flavor & Fragrance Industry: Serves as a precursor for lactones and other compounds that contribute to complex flavor and aroma profiles.
• Organic Synthesis Reagent: Employed in asymmetric synthesis, Michael additions, and cyclization reactions to construct complex organic frameworks.
• Chemical Research & Development: A valuable standard and starting material in academic and industrial R&D for exploring new synthetic methodologies.

Basic Information

Item	Detail
Product Name	Diethyl 3-Hydroxyglutarate
CAS No.	32328-03-3
Molecular Formula	C9H16O5
Molecular Weight	204.22 g/mol
Synonyms	3-Hydroxyglutaric Acid Diethyl Ester; Diethyl 3-Hydroxypentanedioate; Ethyl 3-Hydroxyglutarate; 3-Hydroxy-1,5-pentanedioic Acid Diethyl Ester; DEHG; Diethyl 3-Hydroxy-1,5-pentanedioate
EINECS	Contact for details

Quality Control

Our Diethyl 3-Hydroxyglutarate is produced under a strict quality management system. Every batch undergoes comprehensive analytical testing, including chromatography (HPLC, GC) and spectroscopic methods (IR, NMR), to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are provided and available upon request, supporting compliance with cGMP and ISO 9001 standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider holding under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.