Description

(4S)-2,2-Dimethyl-1,3-Dioxolane-4-Acetaldehyde is a high-value chiral building block and protected form of glyceraldehyde. This compound is essential for the stereoselective synthesis of complex molecules, providing a key source of chirality and aldehyde functionality. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and fine chemical industries for the development of active pharmaceutical ingredients (APIs), nucleosides, and natural products.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the asymmetric synthesis of antiviral, anticancer, and other therapeutic agents.
• Nucleoside & Nucleotide Chemistry: Used in the preparation of modified nucleosides and nucleotides for drug discovery and biochemical research.
• Natural Product Synthesis: Serves as a key starting material for constructing complex natural products with defined stereochemistry.
• Carbohydrate Chemistry: Acts as a protected glyceraldehyde equivalent for the synthesis of sugars and sugar analogs.
• Asymmetric Catalysis & Ligand Development: Employed in the preparation of chiral ligands and catalysts for enantioselective transformations.
• Fine Chemical & Specialty Material Production: Utilized in the manufacture of high-value specialty chemicals requiring specific stereochemical configurations.

Basic Information

Product Name	(4S)-2,2-Dimethyl-1,3-Dioxolane-4-Acetaldehyde
CAS No.	32233-44-6
Molecular Formula	C7H12O3
Molecular Weight	144.17 g/mol
Synonyms	(S)-2,2-Dimethyl-1,3-dioxolane-4-acetaldehyde; (S)-4-Formylmethyl-2,2-dimethyl-1,3-dioxolane; (S)-1,2-O-Isopropylidene-glyceraldehyde; (S)-Glyceraldehyde Acetonide; (S)-1,2-O-Isopropylidene-D-glyceraldehyde; (S)-2,3-O-Isopropylidene-D-glyceraldehyde; (4S)-(-)-2,2-Dimethyl-1,3-dioxolane-4-acetaldehyde; D-Glyceraldehyde Acetonide
EINECS	250-935-5

Quality Control

Our (4S)-2,2-Dimethyl-1,3-Dioxolane-4-Acetaldehyde is produced under strict quality management systems. Each batch is subjected to rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed specifications for identity, purity, and enantiomeric excess are provided to guarantee reproducible performance in your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is easily oxidized and should be stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.