Description

(3Ar,4R,5R,6As)-Hexahydro-2-Oxo-5-[(Tetrahydro-2H-Pyran-2-Yl)Oxy]-2H-Cyclopenta[B]Furan-4-Carboxaldehyde is a high-purity chiral intermediate of significant importance in advanced organic synthesis. Its complex, functionalized cyclopentane-furanone core structure makes it a valuable building block for the construction of biologically active molecules. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for complex, stereochemically defined targets.
• Asymmetric Synthesis: Utilized as a sophisticated starting material or intermediate in catalytic asymmetric reactions to introduce multiple stereocenters.
• Natural Product Synthesis: Serves as a core structural motif or advanced intermediate in the total synthesis of complex natural products with cyclopentanoid frameworks.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and the preparation of compound libraries for biological screening.
• Process Chemistry Development: Used in scaling up synthetic routes for potential drug candidates, where high enantiomeric purity is critical.
• Academic Research: A valuable compound for methodological studies in organic chemistry, exploring new reaction pathways and protecting group strategies.

Basic Information

Product Name	(3Ar,4R,5R,6As)-Hexahydro-2-Oxo-5-[(Tetrahydro-2H-Pyran-2-Yl)Oxy]-2H-Cyclopenta[B]Furan-4-Carboxaldehyde
CAS No.	32233-41-3
Molecular Formula	C₁₃H₁₈O₅
Molecular Weight	254.28 g/mol
Synonyms	5-(Tetrahydro-2H-pyran-2-yloxy)-2-oxohexahydro-2H-cyclopenta[b]furan-4-carboxaldehyde; (3aR,4R,5R,6aS)-Hexahydro-2-oxo-5-[(tetrahydro-2H-pyran-2-yl)oxy]-2H-cyclopenta[b]furan-4-carboxaldehyde; 4-Formyl-5-(tetrahydropyran-2-yloxy)hexahydro-2H-cyclopenta[b]furan-2-one; THP-protected aldehyde cyclopentanone derivative; Chiral THP-ether aldehyde lactone.
EINECS	Contact for details

Quality Control

Our (3Ar,4R,5R,6As)-Hexahydro-2-Oxo-5-[(Tetrahydro-2H-Pyran-2-Yl)Oxy]-2H-Cyclopenta[B]Furan-4-Carboxaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the primary container to maximize shelf life.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.