Description

3α,11β,17,21-Tetrakis(Trimethylsiloxy)-5α-Pregnan-20-One o-Methyl Oxime is a high-purity, advanced pharmaceutical intermediate characterized by its specific steroid backbone modified with multiple trimethylsilyl (TMS) protecting groups. This compound is critical for researchers and manufacturers requiring precise chemical modifications in complex synthetic pathways, particularly in steroid chemistry. Its primary value lies in serving as a key protected intermediate for the synthesis of more complex steroid derivatives and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of complex steroid-based active pharmaceutical ingredients (APIs).
• Steroid Derivative Synthesis: Used in research and development for creating novel steroid analogs with modified biological activity.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for steroid production under GMP or non-GMP conditions.
• Biochemical Research: Serves as a reference standard or a precursor in studies investigating steroid hormone pathways and receptor interactions.
• Fine Chemical Production: Utilized in the manufacture of high-value, specialty chemicals for the life sciences sector.

Basic Information

Product Name	3α,11β,17,21-Tetrakis(Trimethylsiloxy)-5α-Pregnan-20-One o-Methyl Oxime
CAS No.	32221-30-0
Molecular Formula	C₃₃H₆₇NO₅Si₄
Molecular Weight	658.2 g/mol
Synonyms	5α-Pregnan-20-one, 3,11,17,21-tetrakis[(trimethylsilyl)oxy]-, O-methyloxime; 3,11,17,21-Tetrakis-O-(trimethylsilyl)-5α-pregnan-20-one O-methyloxime; 5α-Pregnan-3α,11β,17,21-tetrol 20-one O-methyloxime tetrakis(trimethylsilyl) ether; Tetrakis(trimethylsiloxy)pregnanone methyloxime; Steroid TMS derivative (oxime).
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for this advanced intermediate. Production adheres to internal specifications designed to meet the exacting requirements of pharmaceutical and research applications. Every batch is analyzed using advanced techniques including HPLC, GC, and NMR to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.