Description

o-[[2,3-Bis(Trimethylsiloxy)Propoxy](Trimethylsilyloxy)Phosphinyl]-n-(Trimethylsilyl)-L-Serine (Trimethylsilyl) Ester is a sophisticated, multi-functional organosilicon derivative of the amino acid L-serine, designed for advanced synthetic applications. Its primary value lies in its role as a highly effective protecting group reagent, particularly for sensitive functional groups in complex organic and peptide synthesis. This compound is essential for researchers and manufacturers in pharmaceutical development and fine chemical production who require precise control over reaction pathways and product purity.

Application

• Peptide Synthesis: As a key protecting group reagent for serine and other amino acid side chains, preventing unwanted side reactions during coupling steps.
• Pharmaceutical Intermediate: Used in the synthesis of complex drug molecules, particularly those requiring selective protection and deprotection strategies.
• Organometallic Chemistry: Serves as a precursor or ligand in catalytic systems due to its silicon-based functional groups.
• Advanced Material Research: Employed in the development of silicon-containing polymers and hybrid organic-inorganic materials.
• Glycopeptide Synthesis: Facilitates the synthesis of glycopeptides by protecting hydroxyl groups on serine and other residues.
• Process Chemistry: Used in scale-up processes for the production of high-value active pharmaceutical ingredients (APIs).

Basic Information

Product Name	o-[[2,3-Bis(Trimethylsiloxy)Propoxy](Trimethylsilyloxy)Phosphinyl]-n-(Trimethylsilyl)-L-Serine (Trimethylsilyl) Ester
CAS No.	32204-75-4
Molecular Formula	C21H52NO8PSi5
Molecular Weight	~ 626.1 g/mol
Synonyms	L-Serine, O-[[2,3-bis[(trimethylsilyl)oxy]propoxy](trimethylsilyloxy)phosphinyl]-N-(trimethylsilyl)-, (trimethylsilyl) ester; N,O-Bis(trimethylsilyl)-O-[[2,3-bis(trimethylsiloxy)propoxy](trimethylsilyloxy)phosphinyl]serine trimethylsilyl ester; Serine derivative, TMS-protected; Silicon-protected L-serine phosphonate ester; Amino acid silylating agent 32204-75-4.
EINECS	Contact for details

Quality Control

Our production of this advanced synthetic reagent adheres to strict quality protocols to ensure batch-to-batch consistency and high purity for sensitive research and production applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and GC to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.