Description

(1R)-1,2,3,4,4A,4Bα,5,8,8A,9,10,10Aα-Dodecahydro-8α,8Aα-Dihydroxy-1,4Aβ-Dimethyl-7-Isopropylphenanthrene-1α-Carboxylic Acid Methyl Ester is a high-purity, complex diterpenoid derivative with a defined stereochemistry, serving as a critical advanced pharmaceutical intermediate and a valuable scaffold in organic synthesis. Its intricate polycyclic structure makes it an essential building block for research and development in medicinal chemistry, particularly for exploring novel bioactive compounds. This compound is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of steroids, terpenoids, and other complex natural product analogs.

Application

• Pharmaceutical Intermediate: Key synthetic precursor for the development of novel steroid-like drugs and terpenoid-based therapeutics.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Organic Synthesis Building Block: Employed in complex multi-step syntheses to construct intricate polycyclic frameworks found in natural products.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Biochemical Research: Potential tool compound for studying enzyme interactions and biological pathways related to terpenoid metabolism.
• Fine Chemical Production: Intermediate in the custom synthesis of specialty chemicals for academic and industrial research.

Basic Information

Product Name	(1R)-1,2,3,4,4A,4Bα,5,8,8A,9,10,10Aα-Dodecahydro-8α,8Aα-Dihydroxy-1,4Aβ-Dimethyl-7-Isopropylphenanthrene-1α-Carboxylic Acid Methyl Ester
CAS No.	32111-52-7
Molecular Formula	C22H34O4
Molecular Weight	362.50 g/mol
Synonyms	Methyl (1R,4aS,4bR,8aR,10aS)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,4b,5,6,8a,9,10,10a-dodecahydrophenanthrene-1-carboxylate; 8α,8aα-Dihydroxy-1,4aβ-dimethyl-7-isopropyl-1,2,3,4,4a,4b,5,6,8a,9,10,10a-dodecahydrophenanthrene-1α-carboxylic acid methyl ester; (1R,4aS,4bR,8aR,10aS)-1,4a-Dimethyl-7-(propan-2-yl)-1,2,3,4,4a,4b,5,6,8a,9,10,10a-dodecahydrophenanthrene-1-carboxylic acid methyl ester; Diterpenoid Methyl Ester; CAS 32111-52-7
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, and NMR to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications for assay, related substances, and residual solvents. Our quality commitment aligns with the standards expected by GMP-oriented facilities for non-GMP starting materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.