Description

(2R)-2-Hydroxy-2-Isobutylbutanedioic Acid 1-Methyl 4-[(1R,7Aα)-Hexahydro-1H-Pyrrolizin-1-Yl]Methyl Ester is a high-purity chiral intermediate of significant importance in advanced organic synthesis. Its complex stereochemistry makes it a critical building block for the development of enantiomerically pure pharmaceuticals and fine chemicals. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of complex active molecules.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and production of enantiomerically pure active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Utilized as a sophisticated building block in catalytic and stoichiometric asymmetric synthesis to introduce specific stereocenters.
• Agrochemical Development: Serves as a precursor in the synthesis of advanced, biologically active compounds for crop protection.
• Fine Chemical Manufacturing: Employed in the production of high-value specialty chemicals requiring precise stereochemical control.
• Academic & Industrial Research: Used in chemical research for method development and the study of stereoselective reactions.

Basic Information

Product Name	(2R)-2-Hydroxy-2-Isobutylbutanedioic Acid 1-Methyl 4-[(1R,7Aα)-Hexahydro-1H-Pyrrolizin-1-Yl]Methyl Ester
CAS No.	31948-48-8
Molecular Formula	C17H29NO5
Molecular Weight	327.42 g/mol
Synonyms	Methyl (2R)-2-hydroxy-2-(2-methylpropyl)butanedioate 4-[(1R,7aα)-octahydro-1H-pyrrolizin-1-ylmethyl] ester; L-671,776; (2R)-2-Hydroxy-2-isobutylsuccinic Acid 1-Methyl 4-[(1R,7aα)-Hexahydro-1H-Pyrrolizin-1-yl]methyl Ester; (2R)-2-Hydroxy-2-(2-methylpropyl)butanedioic Acid 1-Methyl 4-[(1R,7aα)-Octahydro-1H-Pyrrolizin-1-yl]methyl Ester; A Chiral Pyrrolizidine Ester Derivative
EINECS	Contact for details

Quality Control

Our (2R)-2-Hydroxy-2-Isobutylbutanedioic Acid 1-Methyl 4-[(1R,7Aα)-Hexahydro-1H-Pyrrolizin-1-Yl]Methyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.