Description

(+/-)-(trans-2-(Trifluoromethyl)Cyclopropyl)Benzene is a high-value fluorinated aromatic building block characterized by its unique cyclopropane ring fused with a trifluoromethyl group. This structure imparts significant lipophilicity and metabolic stability, making it a critical intermediate in advanced synthetic chemistry. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for constructing novel active ingredients. The compound's specific stereochemistry and fluorine content are key to modulating the biological activity and physicochemical properties of final target molecules.

Application

• Pharmaceutical Intermediate: Serves as a privileged scaffold in the synthesis of potential drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used to develop novel herbicides, fungicides, and insecticides where the CF3-cyclopropyl moiety enhances bioavailability and environmental persistence.
• Material Science Precursor: Acts as a monomer or building block for specialty polymers and liquid crystals, leveraging its rigid, fluorinated structure.
• Organic Synthesis & Catalysis Research: Employed in methodological studies for cyclopropanation reactions and as a test substrate in fluorination chemistry.
• Ligand & Catalyst Design: The benzene and cyclopropane rings provide a sterically defined framework for constructing chiral ligands used in asymmetric catalysis.

Basic Information

Product Name	(+/-)-(trans-2-(Trifluoromethyl)Cyclopropyl)Benzene
CAS No.	31501-91-4
Molecular Formula	C10H9F3
Molecular Weight	186.17 g/mol
Synonyms	(±)-trans-2-(Trifluoromethyl)cyclopropylbenzene; 1-[(1R,2S)-2-(Trifluoromethyl)cyclopropyl]benzene (racemic); Benzene, [(1R,2S)-2-(trifluoromethyl)cyclopropyl]-, (±)-; trans-2-Phenyl-1-(trifluoromethyl)cyclopropane; α-(Trifluoromethyl)cyclopropylbenzene; (trans-2-Trifluoromethylcyclopropyl)benzene; 1-(trans-2-(Trifluoromethyl)cyclopropyl)benzene; Racemic trans-Trifluoromethylcyclopropylbenzene
EINECS	Contact for details

Quality Control

Every batch of (+/-)-(trans-2-(Trifluoromethyl)Cyclopropyl)Benzene is produced and analyzed under strict quality management protocols. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles as confirmed by GC, HPLC, and NMR.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and fluorides. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.0%
Water Content (KF)	≤ 0.5%
Trans/Cis Isomer Ratio (GC)	≥ 95:5

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.