Description

(S)-4,5-Didehydropipecolic Acid CAS NO 31456-71-0 is a high-purity, non-proteinogenic amino acid derivative characterized by its unique piperidine ring structure with an unsaturated bond. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the construction of complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and specialized chemical libraries.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, particularly in medicinal chemistry programs targeting neurological and metabolic disorders.
• Peptidomimetics Research: Used to incorporate constrained, unsaturated amino acid motifs into peptide backbones to enhance metabolic stability and biological activity.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to introduce stereogenic centers.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Agrochemical Development: Serves as a building block for novel, bioactive compounds in crop protection research.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and for creating specialized compound collections for high-throughput screening.

Basic Information

Product Name	(S)-4,5-Didehydropipecolic Acid
CAS No.	31456-71-0
Molecular Formula	C6H7NO2
Molecular Weight	125.13 g/mol
Synonyms	(S)-4,5-Dehydropipecolic Acid; (2S)-4,5-Didehydropipecolic Acid; (S)-1,2,3,6-Tetrahydropyridine-2-carboxylic Acid; (S)-δ4,5-Pipecolic Acid; (S)-4,5-Didehydrohomoproline; L-4,5-Didehydropipecolic Acid
EINECS	Contact for details

Quality Control

Our (S)-4,5-Didehydropipecolic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and chiral excess is supplied with every order.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.