Description

trans-2-(Methoxycarbonyl)Cyclobutane-1-Carboxylic Acid is a high-purity, functionalized cyclobutane derivative serving as a critical chiral building block in advanced organic synthesis. Its rigid, strained four-membered ring structure and dual carboxylic acid/ester functionality make it a valuable precursor for constructing complex molecular architectures. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel drug candidates, particularly in protease inhibitor and constrained peptide mimetic research.
• Agrochemical Synthesis: Building block for creating advanced herbicides and pesticides with specific stereochemical requirements.
• Ligand and Catalyst Development: Precursor for synthesizing novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Monomer or cross-linking agent for developing polymers with unique thermal and mechanical properties derived from the cyclobutane ring.
• Academic & Contract Research: Essential reagent for methodological studies in ring-opening and ring-expansion reactions of strained carbocycles.
• Fine Chemical Production: Used in the multi-step synthesis of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.

Basic Information

Product Name	trans-2-(Methoxycarbonyl)Cyclobutane-1-Carboxylic Acid
CAS No.	31420-60-7
Molecular Formula	C7H10O4
Molecular Weight	158.15 g/mol
Synonyms	trans-1-Carboxy-2-methoxycarbonylcyclobutane; trans-Cyclobutane-1,2-dicarboxylic acid 2-methyl ester; (1R,2S)-rel-2-(Methoxycarbonyl)cyclobutane-1-carboxylic Acid; (1S,2R)-rel-2-(Methoxycarbonyl)cyclobutane-1-carboxylic Acid; Methyl trans-1,2-cyclobutanedicarboxylate-1-carboxylic acid; trans-2-Carbomethoxycyclobutane-1-carboxylic Acid; Cyclobutane-1,2-dicarboxylic acid, 2-methyl ester, (1R,2S)-rel-
EINECS	Contact for details

Quality Control

Our trans-2-(Methoxycarbonyl)Cyclobutane-1-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity assessment, to ensure it meets the exacting standards required for research and process development. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and chiral excess is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (trans isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.