Description

5-Trifluoromethyl-Pyridine-2-Carbaldehyde is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a reactive aldehyde group and a stable trifluoromethyl substituent, makes it indispensable for introducing fluorine-containing motifs into target molecules. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used to construct advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing novel nitrogen-containing ligands for transition metal catalysis.
• Material Science Research: Employed in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Useful for creating fluorinated probes and tags for studying biological systems and drug-target interactions.

Basic Information

Product Name	5-Trifluoromethyl-Pyridine-2-Carbaldehyde
CAS No.	31224-82-5
Molecular Formula	C7H4F3NO
Molecular Weight	175.11 g/mol
Synonyms	2-Formyl-5-(trifluoromethyl)pyridine; 5-(Trifluoromethyl)picolinaldehyde; 5-(Trifluoromethyl)-2-pyridinecarboxaldehyde; 2-Pyridinecarboxaldehyde, 5-(trifluoromethyl)-; α-Trifluoromethylpicolinaldehyde; 5-Trifluoromethyl-2-formylpyridine; 5-Trifluoromethylpicolinaldehyde
EINECS	Contact for details

Quality Control

Our 5-Trifluoromethyl-Pyridine-2-Carbaldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high chemical purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and impurity profiles. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is easily oxidized and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.