Description

1-Cyclopropyl-4,4,4-Trifluoro-1,3-Butanedione is a specialized fluorinated diketone building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity of the 1,3-diketone moiety combined with the electronic influence of the trifluoromethyl and cyclopropyl groups, enabling the construction of complex heterocyclic and fluorinated molecular architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries seeking to introduce fluorinated motifs and enhance the metabolic stability of lead compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those containing fluorinated heterocycles like pyrazoles and isoxazoles.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides where the CF3 group improves biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a chelating agent for metal ions in the preparation of catalysts and metal-organic frameworks (MOFs).
• Material Science Research: Employed as a monomer or cross-linking agent in the development of specialty polymers with tailored thermal and chemical resistance properties.
• Chemical Biology Probes: Utilized to create fluorinated analogs of natural products or biomarkers for studying biological pathways and drug-target interactions.

Basic Information

Product Name	1-Cyclopropyl-4,4,4-Trifluoro-1,3-Butanedione
CAS No.	30923-69-4
Molecular Formula	C7H7F3O2
Molecular Weight	180.13 g/mol
Synonyms	4,4,4-Trifluoro-1-cyclopropyl-1,3-butanedione; 1-Cyclopropyl-4,4,4-trifluorobutane-1,3-dione; Cyclopropyl trifluoroacetyl ketone; 3-Cyclopropyl-2,4-dioxo-1,1,1-trifluorobutane; 1-Cyclopropyl-4,4,4-trifluoro-1,3-butanedione; 3-Cyclopropyl-1,1,1-trifluoro-2,4-butanedione; CF3COCH2COc-C3H5
EINECS	Contact for details

Quality Control

Our 1-Cyclopropyl-4,4,4-Trifluoro-1,3-Butanedione is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material meets the high standards required for research and scale-up applications in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which may affect product stability and performance. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.