Description

(20R)-17,21-[(tert-Butylboranediyl)Bis(Oxy)]-20-Hydroxypregn-4-En-3-One is a high-purity, synthetic steroid derivative featuring a unique boronate ester protecting group. This compound serves as a critical advanced intermediate in the synthesis of complex steroid-based active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel corticosteroids and other therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potent corticosteroid drugs.
• Steroid Chemistry Research: Used in academic and industrial research to explore new steroid derivatives and their biological activities.
• Process Development: Serves as a reference standard and starting material for optimizing synthetic routes in API manufacturing.
• Protecting Group Chemistry: The tert-butylboranediyl group is utilized to protect specific hydroxyl functionalities during multi-step syntheses.
• Biochemical Tool Compound: Potential use in studying steroid hormone receptor interactions and metabolic pathways.

Basic Information

Product Name	(20R)-17,21-[(tert-Butylboranediyl)Bis(Oxy)]-20-Hydroxypregn-4-En-3-One
CAS No.	30888-43-8
Molecular Formula	C₂₅H₃₉BO₄
Molecular Weight	414.39 g/mol
Synonyms	20-Hydroxy-17,21-O-(tert-butylboranediyl)pregn-4-ene-3,20-dione; 17,21-O-(tert-Butylboranediyl)-20-hydroxypregn-4-ene-3,20-dione; 20-Hydroxypregn-4-ene-3,20-dione 17,21-(tert-butylboranediyl) acetal; Pregn-4-ene-3,20-dione, 17,21-[(1,1-dimethylethyl)boranediyl]bis(oxy)]-, (20R)-; Steroid boronate ester intermediate
EINECS	Contact for details

Quality Control

Every batch of our (20R)-17,21-[(tert-Butylboranediyl)Bis(Oxy)]-20-Hydroxypregn-4-En-3-One is manufactured under controlled conditions and undergoes rigorous analytical testing. We ensure compliance with stringent internal specifications suitable for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.