Description

(20S)-20,21-[(tert-Butylboranediyl)Bis(Oxy)]-5α-Pregnane-3α,11β-Diol is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and boronate ester functional group. This compound matters for its role as a critical building block in the synthesis of complex steroid-based active pharmaceutical ingredients (APIs) and research compounds. It is primarily needed by pharmaceutical R&D laboratories, process development chemists, and manufacturers specializing in targeted steroid synthesis and novel therapeutic development.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex steroid-derived active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for the design and development of new therapeutic agents targeting hormone receptors.
• Process Chemistry: Serves as a critical building block in process development and scale-up for commercial pharmaceutical manufacturing.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Biochemical Research: Utilized in studies investigating steroid metabolism, enzyme inhibition, and receptor-ligand interactions.
• Custom Synthesis: A starting material for the custom synthesis of specialized steroid analogs for clinical and pre-clinical research.

Basic Information

Product Name	(20S)-20,21-[(tert-Butylboranediyl)Bis(Oxy)]-5α-Pregnane-3α,11β-Diol
CAS No.	30888-37-0
Molecular Formula	C25H43BO4
Molecular Weight	418.42 g/mol
Synonyms	5α-Pregnane-3α,11β-diol, 20,21-[(1,1-dimethylethyl)boranediyl]bis[oxy]-, (20S)-; (20S)-20,21-[(tert-Butylboranediyl)bis(oxy)]-5α-pregnane-3α,11β-diol; 3α,11β-Dihydroxy-5α-pregnan-20S-yl tert-butylboronate; Steroid boronate ester intermediate; tert-Butyl (20S)-3α,11β-dihydroxy-5α-pregnan-20-yl boronate; Pregnane boronic ester derivative
EINECS	Contact for details

Quality Control

Our (20S)-20,21-[(tert-Butylboranediyl)Bis(Oxy)]-5α-Pregnane-3α,11β-Diol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure compliance with exacting standards for pharmaceutical intermediates. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccant packs or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.