Description

(20R)-3α,11β-Dihydroxy-17,20-[(Methylboranediyl)Bisoxy]-5β-Pregnane CAS NO 30882-62-3 is a high-purity, synthetic pregnane derivative featuring a unique methylboranediyl bisoxy bridge. This compound is a critical advanced pharmaceutical intermediate (API intermediate) valued for its precise stereochemistry and functional groups, which serve as key building blocks in complex organic syntheses. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development and production of specialized steroid-based therapeutics and novel bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of complex steroid-based active pharmaceutical ingredients (APIs).
• Steroid Research & Development: Used as a reference standard and a precursor in medicinal chemistry for exploring new therapeutic agents targeting hormonal pathways.
• Biochemical Research: Employed in studies investigating enzyme-substrate interactions, receptor binding assays, and metabolic pathways due to its specific structural configuration.
• Process Chemistry: Acts as a crucial intermediate in scaling up production processes for target molecules in GMP (Good Manufacturing Practice) environments.
• Custom Synthesis: Provides a versatile starting point for the custom synthesis of labeled compounds (e.g., deuterated, C13) for analytical and diagnostic applications.

Basic Information

Product Name	(20R)-3α,11β-Dihydroxy-17,20-[(Methylboranediyl)Bisoxy]-5β-Pregnane
CAS No.	30882-62-3
Molecular Formula	C₂₂H₃₇BO₄
Molecular Weight	376.34 g/mol
Synonyms	3α,11β-Dihydroxy-17,20-[(methylboranediyl)bis(oxy)]-5β-pregnane; (20R)-17,20-[(Methylboranediyl)bis(oxy)]-3α,11β-dihydroxy-5β-pregnane; 5β-Pregnane-3α,11β-diol, 17,20-[(methylboranediyl)bis(oxy)]-, (17R,20R)-; Pregnane derivative with methylboranediyl bridge; Steroid-boronate intermediate; API Intermediate 30882-62-3
EINECS	Contact for details

Quality Control

Our (20R)-3α,11β-Dihydroxy-17,20-[(Methylboranediyl)Bisoxy]-5β-Pregnane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ICH guidelines for stability and impurity characterization, supporting its use in research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.