Description

(20R)-17,20-[(tert-Butylboranediyl)Bis(Oxy)]-5β-Pregnan-3α-Ol CAS NO 30882-59-8 is a high-purity, synthetic steroid derivative featuring a unique tert-butylboranediyl bis(oxy) protecting group. This compound is a critical advanced intermediate in the synthesis of complex pharmaceutical actives, particularly in the development of novel corticosteroids and other steroidal therapeutics. It is primarily utilized by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers requiring precise, high-quality building blocks for complex organic synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the multi-step production of potent corticosteroid drugs and other steroidal active pharmaceutical ingredients (APIs).
• Organic Synthesis Building Block: Used in research and development for constructing complex molecular architectures, leveraging its protected diol functionality for selective reactions.
• Medicinal Chemistry Research: Employed in the discovery and optimization of new therapeutic agents targeting inflammatory pathways and hormonal receptors.
• Process Chemistry & Scale-Up: Integral to developing and optimizing robust, scalable manufacturing routes for steroidal compounds in GMP environments.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(20R)-17,20-[(tert-Butylboranediyl)Bis(Oxy)]-5β-Pregnan-3α-Ol
CAS No.	30882-59-8
Molecular Formula	C29H51BO3
Molecular Weight	458.53 g/mol
Synonyms	5β-Pregnan-3α-ol, 17,20-[(1,1-dimethylethyl)boranediyl]bis[oxy]-, (17R,20R)-; (17R,20R)-17,20-[(tert-Butylboranediyl)bis(oxy)]-5β-pregnan-3α-ol; 17,20-O-(tert-Butylboranediyl)-5β-pregnan-3α-ol; Steroid boronic ester intermediate; Pregnane boronate derivative
EINECS	Contact for details

Quality Control

Every batch of (20R)-17,20-[(tert-Butylboranediyl)Bis(Oxy)]-5β-Pregnan-3α-Ol is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C to maintain stability and prevent degradation due to oxidation and moisture absorption. Allow the container to reach room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.