Description

4-Bromo-1-tert-Butyl-2-Methoxybenzene is a versatile brominated aromatic intermediate with a sterically hindered tert-butyl group and a methoxy substituent. This molecular architecture makes it a valuable synthon for constructing complex organic frameworks, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the fine chemical and life sciences industries for applications requiring selective functionalization and controlled reactivity.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring sterically hindered aromatic systems.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators where the bromine atom serves as a handle for further coupling reactions.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized phosphine or N-heterocyclic carbene (NHC) ligands used in transition metal catalysis.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, or advanced polymers due to its electron-donating methoxy group and modifiable bromine site.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Chemical Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	4-Bromo-1-tert-Butyl-2-Methoxybenzene
CAS No.	30788-02-4
Molecular Formula	C11H15BrO
Molecular Weight	243.14 g/mol
Synonyms	4-Bromo-2-methoxy-tert-butylbenzene; 1-Bromo-4-tert-butyl-2-methoxybenzene; 2-Methoxy-5-tert-butylbromobenzene; 5-tert-Butyl-2-bromoanisole; 4-Bromo-2-methoxy-1-(1,1-dimethylethyl)benzene; 2-Bromo-5-tert-butylanisole; 1-tert-Butyl-4-bromo-2-methoxybenzene
EINECS	Contact for details

Quality Control

Our 4-Bromo-1-tert-Butyl-2-Methoxybenzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide full traceability and a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in cGMP environments and research requiring the highest material integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.