Description

Triethyl Phosphonoacetate is a high-purity organophosphorus compound, specifically a phosphonate ester, serving as a critical building block in advanced organic synthesis. Its primary value lies in its role as a versatile reagent for the Horner-Wadsworth-Emmons (HWE) olefination reaction, enabling the efficient and stereoselective formation of carbon-carbon double bonds. This makes it an indispensable material for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise and scalable methods for constructing complex molecules.

Application

• Pharmaceutical Intermediates: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing α,β-unsaturated esters and other olefinic structures.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators that require specific alkene functionalities.
• Fine Chemical Manufacturing: Employed as a precursor for flavors, fragrances, and advanced materials where controlled olefination is crucial.
• Academic & Industrial R&D: A staple reagent in laboratory-scale research for method development and the synthesis of novel organic compounds.
• Peptide Mimetics & Bioactive Molecules: Facilitates the introduction of phosphonate groups or vinylogous structures into molecules designed for biological activity studies.

Basic Information

Product Name	Triethyl Phosphonoacetate
CAS No.	30492-56-9
Molecular Formula	C8H17O5P
Molecular Weight	224.19 g/mol
Synonyms	(Triethoxyphosphoryl)acetic acid ethyl ester; Ethyl (diethoxyphosphinyl)acetate; Diethyl (ethoxycarbonylmethyl)phosphonate; Acetic acid, 2-(triethoxyphosphinyl)-, ethyl ester; Triethyl (ethoxycarbonylmethyl)phosphonate; Phosphonoacetic acid triethyl ester; TEPA; Triethyl carboxymethylphosphonate
EINECS	250-215-6

Quality Control

Our Triethyl Phosphonoacetate is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. The product is moisture-sensitive; ensure containers are kept tightly sealed when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.430 - 1.435
Density (20°C)	1.120 - 1.135 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.