Description

Grayanotoxin Vi is a potent diterpenoid neurotoxin belonging to the grayanotoxin family, identified by CAS NO 30460-36-7. This compound is of significant interest in pharmacological research due to its specific action on voltage-gated sodium channels, which modulates neuronal excitability. It serves as a critical reference standard and research tool for neuroscientists, toxicologists, and pharmaceutical developers studying channelopathies, natural product toxicology, and novel analgesic or cardiocative agent pathways.

Application

• Pharmacological Research: Used as a precise biochemical tool to study the modulation and gating mechanisms of voltage-gated sodium (Nav) channels in neuronal and cardiac tissues.
• Toxicology & Safety Assessment: Acts as a key analytical standard for the detection and quantification of grayanotoxins in forensic analysis, food safety (e.g., honey contamination), and environmental monitoring.
• Neuroscience Studies: Employed in electrophysiology experiments to induce persistent activation of sodium channels, aiding in the investigation of neuronal signaling, pain pathways, and seizure mechanisms.
• Drug Discovery & Development: Serves as a lead compound or a molecular probe for designing and screening new therapeutic agents targeting ion channels for conditions like chronic pain, arrhythmias, and epilepsy.
• Natural Product Chemistry: Utilized as a high-purity reference material for the isolation, characterization, and quality control of related diterpenoids in botanical extracts, such as those from Rhododendron species.
• Academic & Clinical Research: Provides a reliable standard for calibrating analytical instruments (HPLC, LC-MS) in studies investigating plant-derived toxins and their metabolic pathways.

Basic Information

Product Name	Grayanotoxin Vi
CAS No.	30460-36-7
Molecular Formula	C22H36O7
Molecular Weight	412.52 g/mol
Synonyms	Grayanotoxin VI; Grayanotoxin 6; Grayanotoxin VI (6-deoxygrayanotoxin III); 6-Deoxygrayanotoxin III; 3,5,6,14,16-Pentahydroxygrayan-10(20)-en-9-one; Acetylandromedol (6-deoxy-); Andromedotoxin VI; Rhodojaponin VI; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Every batch of Grayanotoxin Vi is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identification, and impurity profiles is provided with each shipment to support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider conditions under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.