Description

3',5'-Bis(Trifluoromethyl)Acetophenone is a high-value, multi-functional fluorinated aromatic ketone building block. This compound is prized for its unique electronic properties imparted by the two trifluoromethyl groups, which make it a critical intermediate in advanced synthesis. It is primarily sought after by R&D and production chemists in the pharmaceutical, agrochemical, and specialty materials sectors for constructing complex molecules with enhanced bioactivity and stability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in molecules targeting central nervous system (CNS) disorders and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the trifluoromethyl groups contribute to improved lipophilicity and metabolic stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and organometallic chemistry.
• Material Science Research: Employed in the synthesis of monomers for specialty polymers, liquid crystals, and organic electronic materials.
• Fluorine Chemistry Studies: An important compound for academic and industrial research into the effects of polyfluorination on aromatic systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke fine chemicals and reference standards.

Basic Information

Product Name	3',5'-Bis(Trifluoromethyl)Acetophenone
CAS No.	30071-93-3
Molecular Formula	C10H6F6O
Molecular Weight	256.15 g/mol
Synonyms	1-[3,5-Bis(trifluoromethyl)phenyl]ethanone; 3,5-Bis(trifluoromethyl)acetophenone; 3,5-Bis(trifluoromethyl)phenyl methyl ketone; α,α,α,α',α',α'-Hexafluoro-3,5-dimethylacetophenone; 3,5-Di(trifluoromethyl)acetophenone; 3,5-Bis(trifluoromethyl)acetylbenzene; Ethanone, 1-[3,5-bis(trifluoromethyl)phenyl]-
EINECS	Contact for details

Quality Control

Our 3',5'-Bis(Trifluoromethyl)Acetophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong alkalis and sources of fluoride ions. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	40 - 44 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.