Description

Diethyl trans-1,2-Cyclopropanedicarboxylate is a high-purity diester derivative of cyclopropane-1,2-dicarboxylic acid, serving as a versatile and valuable chiral building block in advanced organic synthesis. Its rigid, strained three-membered ring structure makes it a critical intermediate for constructing complex molecular architectures with precise stereochemistry. This compound is essential for research and production in the pharmaceutical and agrochemical industries, where it is used to develop active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing cyclopropane motifs, which are prevalent in various therapeutic agents.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the cyclopropane ring contributes to biological activity and stability.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to control stereoselectivity.
• Material Science Research: Employed in the development of specialty polymers and functional materials with unique thermal or mechanical properties derived from the strained ring system.
• Fine Chemical Production: Acts as a building block for fragrances, flavors, and other high-value specialty chemicals requiring specific stereochemistry.
• Academic & R&D: A standard reagent in organic chemistry laboratories for method development and studying cyclopropanation reactions and ring-strain chemistry.

Basic Information

Product Name	Diethyl trans-1,2-Cyclopropanedicarboxylate
CAS No.	3999-55-1
Molecular Formula	C9H14O4
Molecular Weight	186.21 g/mol
Synonyms	trans-Diethyl 1,2-cyclopropanedicarboxylate; Diethyl (1R,2R)-1,2-cyclopropanedicarboxylate; Diethyl (1S,2S)-1,2-cyclopropanedicarboxylate; Ethyl trans-1,2-cyclopropanedicarboxylate; 1,2-Cyclopropanedicarboxylic acid, diethyl ester, trans-; trans-Cyclopropane-1,2-dicarboxylic acid diethyl ester; Diethyl cyclopropane-1,2-dicarboxylate (trans)
EINECS	Contact for details

Quality Control

Our Diethyl trans-1,2-Cyclopropanedicarboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC and GC, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (trans isomer)
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.440 - 1.445
Density (g/mL at 20°C)	1.090 - 1.110

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.