Description

Zinc Bis(Hexamethyldisilazide) CAS NO 3999-27-7 is a highly reactive organometallic compound that serves as a powerful and versatile zinc amide base and precursor. Its primary value lies in its ability to facilitate efficient deprotonation and transmetalation reactions under mild conditions, which is critical for synthesizing complex molecules. This reagent is essential for researchers and process chemists in the pharmaceutical, advanced materials, and fine chemical industries, particularly for the development of catalysts and novel organic frameworks.

Application

• As a strong, non-nucleophilic base in organic synthesis for the deprotonation of weak acids.
• Key precursor for the preparation of zinc-containing catalysts used in polymerization and cross-coupling reactions.
• Transmetalation agent in the synthesis of other organometallic compounds for materials science.
• Reagent in the production of semiconductor nanomaterials and quantum dots via chemical vapor deposition (CVD) or atomic layer deposition (ALD) processes.
• Used in pharmaceutical research for the synthesis of complex drug intermediates and active pharmaceutical ingredients (APIs).
• Employed in the development of advanced ceramics and metal-organic frameworks (MOFs).

Basic Information

Product Name	Zinc Bis(Hexamethyldisilazide)
CAS No.	3999-27-7
Molecular Formula	C12H36N2Si4Zn
Molecular Weight	418.26 g/mol
Synonyms	Bis(hexamethyldisilazido)zinc; Zinc Hexamethyldisilazide; Zinc HMDS; Zn(HMDS)2; Zinc bis(trimethylsilyl)amide; Zinc 1,1,1,3,3,3-hexamethyldisilazan-2-ide; Zinc 1,1,1,3,3,3-hexamethyldisilazide; Zinc(II) bis(hexamethyldisilazide)
EINECS	Contact for details

Quality Control

Our Zinc Bis(Hexamethyldisilazide) is manufactured under stringent conditions to ensure high purity and batch-to-batch consistency. Quality is verified through a comprehensive suite of analytical techniques, including NMR, elemental analysis, and titration. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) in a cool, dry, and well-ventilated area. Due to its hygroscopic and pyrophoric nature, the material must be handled exclusively under inert conditions to prevent degradation or hazardous reactions. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder or crystals
Identification (NMR)	Conforms to structure
Assay (Zinc content)	≥ 95.0%
Purity (by NMR)	≥ 98.0%
Solubility	Soluble in common organic solvents (e.g., toluene, THF, hexanes)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.