Description

1-Bromo-2,4,6-Tri-tert-Butylbenzene is a sterically hindered aromatic bromo compound, valued for its unique reactivity profile as a bulky aryl bromide. This compound matters as a versatile advanced intermediate and ligand precursor in sophisticated organic synthesis, where its tert-butyl groups provide significant steric bulk. It is primarily needed by researchers and manufacturers in the pharmaceutical and specialty chemical sectors for developing catalysts and complex molecular architectures.

Application

• Pharmaceutical Intermediate: Used in the synthesis of complex drug molecules, particularly where steric hindrance is required to control reaction pathways.
• Ligand Synthesis: Serves as a key precursor for the preparation of bulky phosphine and N-heterocyclic carbene (NHC) ligands used in transition metal catalysis.
• Material Science Research: Employed in the development of novel organic electronic materials and polymers, where its structure can influence packing and properties.
• Cross-Coupling Reactions: Acts as a coupling partner in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions, albeit with modified conditions due to steric factors.
• Chemical Standard & Reference: Used as a standard in analytical chemistry for method development and calibration.
• Organic Synthesis Building Block: Provides a sterically protected aryl bromide moiety for constructing highly substituted benzene derivatives and dendrimers.

Basic Information

Product Name	1-Bromo-2,4,6-Tri-tert-Butylbenzene
CAS No.	3975-77-7
Molecular Formula	C18H29Br
Molecular Weight	325.33 g/mol
Synonyms	2,4,6-Tri-tert-butyl-1-bromobenzene; 2,4,6-Tri-tert-butylbromobenzene; 1-Bromo-2,4,6-tris(1,1-dimethylethyl)benzene; Benzene, 1-bromo-2,4,6-tris(1,1-dimethylethyl)-; 2,4,6-Tri-tert-butylphenyl bromide; NSC 163045
EINECS	Contact for details

Quality Control

Our 1-Bromo-2,4,6-Tri-tert-Butylbenzene is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	95 - 99 °C
Heavy Metals	< 10 ppm
Residue on Ignition	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.