Description

(R)-(-)-α-Methoxyphenylacetic Acid CAS NO 3966-32-3 is a high-purity chiral carboxylic acid derivative, serving as a critical building block in asymmetric synthesis. Its primary value lies in its utility as a versatile resolving agent and chiral auxiliary for the production of enantiomerically pure pharmaceuticals and fine chemicals. This compound is essential for research and manufacturing chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly for cardiovascular and central nervous system drugs.
• Chiral Resolving Agent: Used for the optical resolution of racemic mixtures of amines, amino acids, and other chiral bases through diastereomeric salt formation.
• Asymmetric Synthesis: Employed as a chiral auxiliary in stereoselective reactions, including alkylations, aldol reactions, and Diels-Alder cycloadditions.
• Agrochemical Synthesis: Building block for creating chiral herbicides, fungicides, and plant growth regulators with enhanced biological activity.
• Ligand and Catalyst Preparation: Starting material for synthesizing chiral ligands used in transition metal catalysis for asymmetric hydrogenation and cross-coupling.
• Analytical Standard: Serves as a reference standard in chromatographic methods (HPLC, GC) for method development and quality control of chiral compounds.

Basic Information

Product Name	(R)-(-)-α-Methoxyphenylacetic Acid
CAS No.	3966-32-3
Molecular Formula	C10H12O3
Molecular Weight	180.20 g/mol
Synonyms	(R)-(-)-α-Methoxyphenylacetic Acid; (R)-O-Methylmandelic Acid; (R)-(-)-2-Methoxy-2-phenylacetic Acid; (R)-MPA; (R)-Methoxyphenylacetic Acid; (2R)-2-Methoxy-2-phenylacetic Acid; (R)-(-)-O-Methylmandelic Acid; D-α-Methoxyphenylacetic Acid
EINECS	223-562-1

Quality Control

Our (R)-(-)-α-Methoxyphenylacetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing specific results for chiral purity, chemical purity, and identity are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. Due to its nature as a strong acid/organic solvent, ensure containers are kept upright and sealed when not in use to prevent contamination and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Melting Point	65 - 68 °C
Specific Rotation [α]20/D	-150° to -158° (c=1 in methanol)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.