Description

Ethyl Trimethylacetate is a versatile organic ester, also known as ethyl pivalate, valued for its role as a building block and solvent in advanced chemical synthesis. Its sterically hindered structure makes it particularly useful for introducing the bulky pivaloyl (trimethylacetyl) group, which can enhance the stability and performance of final products. This compound is essential for manufacturers and R&D laboratories in the pharmaceutical, agrochemical, and specialty chemical industries seeking reliable, high-purity intermediates.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially those requiring sterically hindered ester groups for metabolic stability.
• Agrochemical Synthesis: Used in the production of pesticides and herbicides where the pivalate moiety can influence biological activity and environmental persistence.
• Polymer & Resin Modifier: Acts as a monomer or modifying agent in the synthesis of specialty polymers, contributing to specific properties like hydrophobicity or UV resistance.
• Flavor & Fragrance Ingredient: Serves as a precursor or solvent in the creation of certain ester-based flavor and fragrance compounds.
• Organic Synthesis Reagent: Employed in esterification and transesterification reactions as both a reagent and a solvent, particularly in reactions sensitive to steric effects.
• Chemical Research & Development: A valuable tool in academic and industrial R&D for exploring new synthetic pathways and creating novel chemical entities.

Basic Information

Product Name	Ethyl Trimethylacetate
CAS No.	3938-95-2
Molecular Formula	C7H14O2
Molecular Weight	130.18 g/mol
Synonyms	Ethyl Pivalate; Pivalic Acid Ethyl Ester; Trimethylacetic Acid Ethyl Ester; Ethyl 2,2-Dimethylpropanoate; 2,2-Dimethylpropanoic Acid Ethyl Ester; NSC 66495; UNII-8VZ5118W5R
EINECS	223-520-7

Quality Control

Every batch of Ethyl Trimethylacetate is manufactured and tested under a strict quality management system to ensure consistency and reliability. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated industries. Specifications can be tailored to meet the rigorous demands of pharmaceutical (USP/EP) or high-purity synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids, bases, and oxidizing agents. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to minimize moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Clear, colorless liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (20°C)	1.390 - 1.395
Density (20°C)	0.855 - 0.865 g/mL
Acidity (as Pivalic Acid)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.