Description

5-(Chloromethyl)-1,2,3-Trimethoxybenzene is a versatile aromatic building block characterized by a reactive chloromethyl group and three methoxy substituents. This compound is of significant value in organic synthesis, serving as a key intermediate for constructing more complex molecules in pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and agrochemical industries for applications such as the synthesis of active pharmaceutical ingredients (APIs) and advanced material precursors.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs), particularly those with substituted benzyl or aryl ether motifs.
• Agrochemical Synthesis: Used in the research and development of herbicides, fungicides, and insecticides, leveraging its reactive site for further functionalization.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in metal-catalyzed coupling reactions and other catalytic processes.
• Material Science Research: Employed in the creation of novel organic compounds for electronic materials, liquid crystals, or polymers.
• Chemical Biology Probes: Useful for synthesizing tagged molecules or probes for studying biological systems and mechanisms.
• Custom Synthesis and Contract Manufacturing: A critical raw material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	5-(Chloromethyl)-1,2,3-Trimethoxybenzene
CAS No.	3840-30-0
Molecular Formula	C10H13ClO3
Molecular Weight	216.66 g/mol
Synonyms	1,2,3-Trimethoxy-5-(chloromethyl)benzene; 3,4,5-Trimethoxybenzyl Chloride; Gallic Acid Trimethyl Ether Chloromethyl Derivative; (3,4,5-Trimethoxyphenyl)methyl Chloride; 3,4,5-Trimethoxybenzyl Chloride; Chloromethyltrimethoxybenzene; 3,4,5-Trimethoxybenzylchloride; 5-(Chloromethyl)-1,2,3-trimethoxy-benzene
EINECS	223-337-5

Quality Control

Our 5-(Chloromethyl)-1,2,3-Trimethoxybenzene is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.