Description

Ethyl 2-Amino-4,4,4-Trifluorobutanoate Hydrochloride is a high-purity, non-natural amino acid derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in the trifluoromethyl group, which imparts unique metabolic stability and lipophilicity to target molecules, making it indispensable for modern drug discovery. This compound is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers for the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated analogs of amino acids and peptides, enhancing drug potency and bioavailability.
• Agrochemical Research: Used in developing novel herbicides and pesticides where the trifluoromethyl group contributes to improved environmental stability and efficacy.
• Proteomics & Biochemistry: Acts as a building block for non-natural amino acids incorporated into proteins and enzymes for structure-activity relationship (SAR) studies.
• Material Science: Serves as a precursor for specialty polymers and liquid crystals where fluorine content modifies surface properties and thermal stability.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs for custom synthesis projects requiring high-purity, fluorinated chiral intermediates.
• Academic Research: Utilized in university and institutional labs for methodological development in asymmetric synthesis and fluorine chemistry.

Basic Information

Product Name	Ethyl 2-Amino-4,4,4-Trifluorobutanoate Hydrochloride
CAS No.	3834-43-3
Molecular Formula	C6H11ClF3NO2
Molecular Weight	221.61 g/mol
Synonyms	Ethyl 2-Amino-4,4,4-Trifluorobutyrate Hydrochloride; 2-Amino-4,4,4-Trifluorobutanoic Acid Ethyl Ester Hydrochloride; 4,4,4-Trifluoro-DL-norvaline Ethyl Ester Hydrochloride; DL-2-Amino-4,4,4-Trifluorobutanoic Acid Ethyl Ester Hydrochloride; Norvaline, 4,4,4-trifluoro-, ethyl ester, hydrochloride; Ethyl α-Amino-γ,γ,γ-trifluorobutyrate Hydrochloride; Ethyl 4,4,4-Trifluoronorvalinate Hydrochloride
EINECS	Contact for details

Quality Control

Our Ethyl 2-Amino-4,4,4-Trifluorobutanoate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the exacting standards required for pharmaceutical and advanced research applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after initial opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee (enantiomeric excess)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.