Description

3,3,3-Trifluoro-2-Hydroxypropylamine Hydrochloride is a high-purity fluorinated organic building block with significant synthetic utility. This compound is valued for its ability to introduce both a trifluoromethyl group and a functionalized amine moiety into target molecules, enhancing their physicochemical properties. It is primarily sought after by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, including protease inhibitors and kinase modulators, where the trifluoromethyl group can improve metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, leveraging the fluorine atoms to enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, contributing to improved dielectric anisotropy and thermal stability.
• Peptide Modification: Employed to incorporate fluorinated amino acid analogs into peptides, a strategy used to study protein interactions and develop therapeutic peptides with enhanced properties.
• Cross-coupling Reagent: Acts as a specialized reagent in palladium-catalyzed cross-coupling reactions to introduce fluorinated alkylamine chains.
• Chemical Research & Development: A versatile building block in academic and industrial R&D for exploring new fluorination methodologies and creating novel chemical entities.

Basic Information

Product Name	3,3,3-Trifluoro-2-Hydroxypropylamine Hydrochloride
CAS No.	3832-24-4
Molecular Formula	C₃H₇ClF₃NO
Molecular Weight	177.54 g/mol
Synonyms	1-Amino-3,3,3-trifluoro-2-propanol hydrochloride; 3-Amino-1,1,1-trifluoro-2-propanol hydrochloride; 3,3,3-Trifluoro-2-hydroxy-1-propanamine hydrochloride; 3,3,3-Trifluoroalaninol hydrochloride; 2-Hydroxy-3,3,3-trifluoropropylamine hydrochloride; (±)-3-Amino-1,1,1-trifluoro-2-propanol hydrochloride; 3,3,3-Trifluoro-2-propanolamine hydrochloride
EINECS	223-327-4

Quality Control

Our 3,3,3-Trifluoro-2-Hydroxypropylamine Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption and decomposition. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.