Description

2-(Diethoxyphosphinyl)-3-Oxobutanoic Acid Ethyl Ester is a high-purity organophosphorus compound, specifically a β-ketophosphonate ester, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a phosphonate and a β-ketoester moiety, makes it an exceptionally versatile reagent for constructing complex molecular frameworks. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to synthesize active pharmaceutical ingredients (APIs), novel crop protection agents, and sophisticated ligands for catalysis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those requiring phosphorus-containing scaffolds or heterocyclic structures.
• Agrochemical Synthesis: Used in the development of novel herbicides, insecticides, and fungicides, leveraging its reactivity to create potent active ingredients.
• Horner-Wadsworth-Emmons (HWE) Reaction Reagent: Acts as a stabilized phosphonate ylide precursor for the stereoselective synthesis of α,β-unsaturated esters and ketones, a fundamental transformation in organic chemistry.
• Ligand and Catalyst Development: Serves as a starting material for the preparation of specialized phosphonate-based ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Research & Development: A valuable tool for medicinal chemists and process chemists exploring new synthetic routes and novel chemical entities.
• Specialty Polymer Modification: Can be incorporated into polymer backbones to impart specific properties like flame retardancy or metal-chelating ability.

Basic Information

Product Name	2-(Diethoxyphosphinyl)-3-Oxobutanoic Acid Ethyl Ester
CAS No.	3730-54-9
Molecular Formula	C10H19O6P
Molecular Weight	266.23 g/mol
Synonyms	Diethyl (2-Ethoxy-2-oxoethyl)(oxo)methylphosphonate; Diethyl (1-Ethoxy-1,3-dioxobutan-2-yl)phosphonate; Ethyl 2-(Diethoxyphosphinyl)-3-oxobutanoate; 3-Oxobutanoic Acid, 2-(Diethoxyphosphinyl)-, Ethyl Ester; Acetoacetic Acid Ethyl Ester Diethyl Phosphonate; (Carbethoxymethyl)(oxo)methylphosphonic Acid Diethyl Ester; HWE Reagent Precursor; β-Ketophosphonate Ester
EINECS	223-097-9

Quality Control

Our production of 2-(Diethoxyphosphinyl)-3-Oxobutanoic Acid Ethyl Ester adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting critical parameters such as assay, impurity profile, and physical characteristics. Our quality systems are designed to meet the exacting standards required for pharmaceutical and advanced chemical synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed to prevent moisture absorption and potential decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.