Description

(2Rs)-2-(4-Butylphenyl)Propanoic Acid is a chiral, non-steroidal anti-inflammatory drug (NSAID) intermediate of significant commercial importance. Its value lies in its role as a key building block for the synthesis of more complex active pharmaceutical ingredients (APIs), particularly profen-class drugs. This compound is essential for manufacturers in the pharmaceutical and fine chemical industries seeking to develop or produce enantiomerically pure therapeutics.

Application

• Pharmaceutical Intermediate: Primary use as a chiral precursor in the synthesis of profen-class NSAIDs, such as ibuprofen and related analogues.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a critical raw material for constructing APIs that target inflammation and pain.
• Chiral Resolution Studies: Used in research and development for method development in separating enantiomers.
• Biochemical Research: Employed as a standard or reagent in studies investigating cyclooxygenase (COX) enzyme inhibition pathways.
• Fine Chemical Production: Acts as a specialized intermediate for creating high-value, complex organic molecules in contract manufacturing.
• Reference Standard: Utilized as a certified reference material (CRM) for quality control and analytical method validation in pharmaceutical labs.

Basic Information

Product Name	(2Rs)-2-(4-Butylphenyl)Propanoic Acid
CAS No.	3585-49-7
Molecular Formula	C₁₃H₁₈O₂
Molecular Weight	206.28 g/mol
Synonyms	2-(4-Butylphenyl)propanoic Acid (Racemate); (±)-2-(4-Butylphenyl)propionic Acid; DL-2-(4-Butylphenyl)propanoic Acid; 4-Butyl-α-methylbenzenacetic Acid; rac-2-(4-Butylphenyl)propanoic Acid; NSC 163022; Benzenepropanoic acid, α-methyl-4-butyl-; Ibuprofen related compound B (butyl analogue)
EINECS	Contact for details

Quality Control

Our (2Rs)-2-(4-Butylphenyl)Propanoic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets exacting standards for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents, strong bases, and heat sources.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	Specified upon grade request
Loss on Drying	≤ 0.5%
Residue on Ignition (Sulfated Ash)	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.