Description

4-(Difluoromethoxy)Benzyl Bromide is a versatile and high-value organobromine building block, essential for introducing the difluoromethoxy benzyl moiety into complex molecular architectures. Its primary commercial value lies in enabling the synthesis of advanced pharmaceutical intermediates and agrochemicals, where the difluoromethoxy group is prized for its ability to modulate lipophilicity and metabolic stability. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS, anti-inflammatory, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group enhances biological activity and environmental profile.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystal compounds for display technologies.
• Organic Electronic Materials: Employed in the development of novel organic semiconductors and charge-transport materials.
• Cross-Coupling Reactions: Functions as a competent electrophile in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to form biaryl structures.
• Peptidomimetics & PROTACs: Useful in medicinal chemistry for the synthesis of peptide mimics and Proteolysis-Targeting Chimeras (PROTACs).
• Fluorine-Containing Polymer Monomers: Acts as a building block for monomers used in specialty polymers with unique surface properties and chemical resistance.

Basic Information

Product Name	4-(Difluoromethoxy)Benzyl Bromide
CAS No.	3447-53-8
Molecular Formula	C8H7BrF2O
Molecular Weight	237.04 g/mol
Synonyms	α-Bromo-4-(difluoromethoxy)toluene; 1-(Bromomethyl)-4-(difluoromethoxy)benzene; (4-(Difluoromethoxy)phenyl)methyl bromide; p-(Difluoromethoxy)benzyl bromide; 4-(Difluoromethoxy)-α-bromotoluene; Benzene, 1-(bromomethyl)-4-(difluoromethoxy)-; Difluoromethoxybenzyl Bromide
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)Benzyl Bromide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment aligns with cGMP principles for pharmaceutical-grade intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.