Description

O,P'-Dde is a specialized chemical compound widely utilized as a key protecting group in solid-phase peptide synthesis (SPPS). Its primary value lies in its orthogonal deprotection characteristics, allowing for the selective and controlled assembly of complex peptide sequences. This makes it an essential reagent for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those developing novel peptide-based therapeutics and diagnostic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a crucial protecting group for the ε-amino group of lysine, enabling the synthesis of complex and branched peptides.
• Orthogonal Deprotection Strategies: Used in Fmoc/t-Bu chemistry where it can be removed under mild conditions (e.g., with hydrazine) without affecting other acid-labile protecting groups.
• Combinatorial Chemistry: Facilitates the generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Bioconjugation: Acts as a versatile linker for the site-specific attachment of peptides to other molecules, surfaces, or solid supports.
• Glycopeptide Synthesis: Protects amino functionalities during the challenging synthesis of glycosylated peptides.
• Research & Development: A fundamental tool in academic and industrial R&D labs for exploring peptide structure-activity relationships.

Basic Information

Product Name	O,P'-Dde
CAS No.	3424-82-6
Molecular Formula	C14H15NO3
Molecular Weight	245.27 g/mol
Synonyms	1-(4,4-Dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl; 1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl; Dde-OH; N-(1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)ethyl); Fmoc-Lys(Dde)-OH (related derivative); 4,4-Dimethyl-2,6-dioxocyclohexylidene ethyl; Lysine Dde protecting group reagent
EINECS	Contact for details

Quality Control

Our O,P'-Dde is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant research and development standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Specification available upon request
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.