Description

Methylcholanthrene-11,12-Epoxide is a high-purity, synthetically derived polycyclic aromatic hydrocarbon (PAH) epoxide, a crucial intermediate in advanced organic synthesis and biochemical research. Its primary value lies in its role as a reactive metabolite analog for mechanistic studies of carcinogenesis and DNA adduct formation. This compound is essential for researchers and manufacturers in the fields of pharmaceutical development, toxicology, and environmental science who require precise and reliable chemical tools for investigative and analytical applications.

Application

• Biochemical Research: Used as a standard or reference compound in studies investigating the metabolic activation pathways of polycyclic aromatic hydrocarbons (PAHs) and their carcinogenic mechanisms.
• Toxicology & Carcinogenicity Studies: Serves as a critical intermediate in laboratory research focused on DNA damage, mutagenesis, and the formation of specific DNA adducts.
• Pharmaceutical Development: Acts as a key synthetic building block or a model compound in the research and development of novel therapeutic agents and inhibitors targeting metabolic enzymes like cytochrome P450.
• Analytical Chemistry: Employed as a high-purity analytical standard for method development and calibration in chromatographic (HPLC, GC) and spectroscopic analyses within environmental and forensic laboratories.
• Academic Research: Utilized in university and institutional labs for advanced organic chemistry projects and educational demonstrations concerning electrophilic reactivity and epoxide chemistry.

Basic Information

Product Name	Methylcholanthrene-11,12-Epoxide
CAS No.	3416-21-5
Molecular Formula	C21H14O
Molecular Weight	282.34 g/mol
Synonyms	11,12-Epoxy-11,12-dihydro-3-methylcholanthrene; 3-Methylcholanthrene 11,12-oxide; 3-MCA 11,12-epoxide; 3-Methylcholanthrene-11,12-epoxide; 11,12-Epoxy-11,12-dihydro-3-methylcholanthrene; MCA Epoxide; 3-Methylcholanthrene epoxide
EINECS	Contact for details

Quality Control

Every batch of Methylcholanthrene-11,12-Epoxide is produced and controlled under a strict quality management system. We employ advanced analytical techniques including HPLC, GC-MS, and NMR to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available upon request to support your research and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.